Masako Harada

简介

I received my B.Sc. degree in Molecular Genetics from King's College London (UK), my Ph.D. in Experimental Oncology from Karolinska Institute (Sweden) and postdoctoral training in Cancer Chemotherapy from Stanford University (USA). My current research interest is to understand the biology and the function of extracellular vesicles (EVs) both in physiological and pathophysiological condition, aiming to develop a novel tool for diagnostics and treatment. Engineered EVs are used for visualization, monitoring and targeted-delivery of oligonucleotide therapeutics, including non-coding RNAs (microRNAs), DNAs and CRSPR-CAS9 as well as low-molecular weight drugs to develop advanced treatment. The ultimate goal of my research is to translate basic scientific findings into clinical applications.

代表成果

• Lohcharoenkal W, Harada M, Lovén J, Meisgen F, Landén NX, Zhang L, Lapins J, Mahapatra KD, Shi H, Nissinen L, Kähäri VM, Ståhle M, Sonkoly E, Grandér D, Arsenian-Henriksson M, Pivarcsi A., MicroRNA-203 Inversely Correlates with Differentiation Grade, Targets c-MYC, and Functions as a Tumor Suppressor in cSCC. J Invest Dermatol (2016) 136(12):2485-2494.
• Harada M., Benito, J., Yamamoto, S., Kaur, S., Arslan, D., Ramirez, S., Jacamo, R., Platanias, L., Matsushita, H., Fujimura, T., Kazuno, S., Kojima, K., Tabe, Y., Konopleva, M., The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Oncotarget (2015) Nov 10;6(35):37930-47
• Xu N, Zhang L, Meisgen F, Harada M, Heilborn J, Homey B, Grander D, Stahle M, Sonkoly E, Pivarcsi A., MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration and Invasion. J Biol Chem. (2012) Jul 10
• Harada M, Pokrovskaja Tamm K, Soderhall S, Heyman M, Grander D, et al. (2012) Involvement of the miR17 pathway in glucocorticoid -induced cell death in pediatric acute lymphoblastic leukemia. Leuk Lymphoma.
• Sonkoly E, Lovén J, Xu N, Meisgen F, Wei T, Brodin P, Jaks V, Kasper M, Shimokawa T, Harada M, Heilborn M, Hedblad M-A, Hippe A, Grandér D, Homey B, Zaphiropoulos PG, Arsenian-Henriksson M, Ståhle M and Pivarcsi A. (2012) MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma. Oncogenesis 1, e3