Christina Chan

About

Our laboratory applies cellular, molecular engineering and systems biology approaches to investigate disease mechanisms. We are studying endoplasmic reticulum (ER) stress related diseases, in particular, we are interested in how fatty acids interact with ER transmembrane sensor proteins to drive the development of cancer metastasis and neurological diseases. Our laboratory also is developing therapeutics using engineering approaches (e.g. drug delivery systems and stem cell engineering techniques) to modulate the pathways altered in these diseases.

Education

• Ph.D, Chemical and Biochemical Engineering, University of Pennsylvania 1990
• M.S., Chemical and Biochemical Engineering, University of Pennsylvania 1986
• B.S., Chemical Engineering, Columbia University 1984

Selected publications

• Splichal, R. C., Chen, K., Walton, S. P., Chan, C., "The Role of Endoplasmic Reticulum Stress on Reducing Recombinant Protein Production in Mammalian Cells", (2024) Biochemical Engineering Journal, https://doi.org/10.1016/j.bej.2024.109434
• Aleksandra Kostina; Yonatan R. Lewis-Israeli; Mishref Abdelhamid; Mitchell A. Gabalski; Artem Kiselev, Brett D. Volmert; Haley Lankerd; Amanda R. Huang; Aaron H. Wasserman; Todd Lydic; Christina Chan; Isoken Olomu; Aitor Aguirre, “ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes”, (2023) Cell Stem Cell, 19: 317-330.
• Thompson, R., Mazur, N., Yang, J., and Chan, C., "Soft Substrates Induce Neural Differentiation via the Neuron Restrictive Silencer Factor", (2022) Biochemical Engineering Journal, 189: 108724.
• Lawson, H. D., Walton, S. P., and Chan, C., “Metal−Organic Frameworks for Drug Delivery: A Design Perspective”, (2021) ACS Applied Materials & Interfaces, 13(6): 7004–7020.