Dr James Sinclair

About

Email Addressj.p.sinclair@abdn.ac.ukTelephone Number+44 (0)1224 272940School/DepartmentSchool of Natural and Computing Sciences Publications Page 1 of 2 Results 1 to 10 of 11 Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease 2015 - PublishedHarrington, C. R., Storey, J. M. D., Clunas, S., Harrington, K. A., Horsley, D., Ishaq, A., Kemp, S. J., Larch, C. P., Marshall, C., Nicoll, S. L., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, L. J., Wischik, C. M. The Journal of Biological Chemistry, vol. 290, no. 17, pp. 10862-10875Contributions to Journals: Articles[ONLINE] DOI: https://doi.org/10.1074/jbc.M114.616029[OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/07bc7740-3cb7-4516-94a1-47a

Selected publications

• Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease 2015 - PublishedHarrington, C. R., Storey, J. M. D., Clunas, S., Harrington, K. A., Horsley, D., Ishaq, A., Kemp, S. J., Larch, C. P., Marshall, C., Nicoll, S. L., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, L. J., Wischik, C. M. The Journal of Biological Chemistry, vol. 290, no. 17, pp. 10862-10875Contributions to Journals: Articles[ONLINE] DOI: https://doi.org/10.1074/jbc.M114.616029[OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/07bc7740-3cb7-4516-94a1-47a9c448bb3a/download
• [ONLINE] DOI: https://doi.org/10.1074/jbc.M114.616029
• [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/07bc7740-3cb7-4516-94a1-47a9c448bb3a/download
• Making thiosulfate-disubstituted-amino-optionally substituted-phenyl-imino-optionally substituted-cyclohexadienylidene-N,N-disubstituted-ammoniums comprises carrying out nitrosyl reduction, thiosulfonic acid formation and oxidative coupling 2015 - PublishedSinclair, J. P., Nicoll, S. L., Storey, J. M. D. Patents: Patents
• New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes 2012 - PublishedBaddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M., Wood, B. A. Patents: Patents
• 3,7-diamino-10H-phenothiazine salts and their use: WO2007110627 2011 - PublishedWischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T. Patents: Patents[OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/e7078526-6ec9-4dfa-83bb-7aeba023bfe1/download
• [OPEN ACCESS] https://aura.abdn.ac.uk/bitstreams/e7078526-6ec9-4dfa-83bb-7aeba023bfe1/download
• Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds 2010 - PublishedWischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P. Patents: Patents
• Methods of synthesis and/or purification of diaminophenothiazinium compounds 2009 - PublishedWischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T. Patents: Patents
• Co-operative stabilisation of a 15-component nanostructure 2007 - PublishedPlater, M. J., Sinclair, J. P., Aiken, S. Journal of Chemical Research, vol. 2007, no. 5, pp. 287-290Contributions to Journals: Articles[ONLINE] DOI: https://doi.org/10.3184/030823407X215636